I3A - Names and Identifiers
Name | Ingenol mebutate
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Synonyms | I3A I3A, PEP005 Ingenol mebutate 3-Angeloylingenol INGENOL-3-ANGELATE 3-Ingenyl angelate Euphorbia factor H1 Euphorbia factor an1 2-Butenoic acid, 2-methyl-, (1ar,2S,5R,5as,6S,8as,9R,10ar)-1A,2,5,5A,6,9,10,10A-octahydro-5,5A-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8A-methanocyclopenta[A]cyclopropa[E]cyclodecen-6-yl ester, (2Z)-
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CAS | 849146-39-0
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I3A - Physico-chemical Properties
Molecular Formula | C25H34O6
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Molar Mass | 430.53 |
Melting Point | 151-154°C |
Boling Point | 338.5±11.0 °C at 760 mmHg |
Solubility | DMSO: >1 mg/mL |
Appearance | Powder |
Color | clear |
Storage Condition | −20°C |
I3A - Risk and Safety
Safety Description | S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
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WGK Germany | 3 |
I3A - Introduction
Ingenol mebutate(Ingenol mebutate) is a natural active compound, which is mainly extracted from the resin and roots of Euphorbiaceae plants. It has special biological activity and can be used in the field of medicine.
Ingenol mebutate has anti-inflammatory, anti-tumor and immunomodulatory activities. It is widely used in the treatment of refractory warts, non-melanin skin cancer and squamous cell carcinoma. It acts by activating apoptosis and inducing inflammatory responses.
The preparation method of Ingenol mebutate is relatively complicated. It is mainly obtained by extracting natural resin and roots from Euphorbiaceae plants, and then undergoing chemical synthesis and purification. The preparation process needs to pay attention to safety, to prevent contact with the skin, inhalation or ingestion.
When using Ingenol mebutate, it is necessary to strictly follow the doctor's instructions and dosage, and comply with the regular safety requirements in the instruction manual. Some potential side effects include local reactions (such as redness, pain, itching, etc.), allergic reactions, and gastrointestinal discomfort. During use, if serious side effects or adverse reactions occur, you should stop using it immediately and consult a doctor.
Last Update:2024-04-09 19:05:56